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KMID : 0378019890320010123
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New Medical Journal
1989 Volume.32 No. 1 p.123 ~ p.128
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The Effects of Carbamazepine on the Serum Electrolytes in Manic Patients
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Abstract
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This study was planned to investigate the acute effect of carbamazepine on the serum sodium, potassium, chloride and calcium and the correlations between changes of the electrolytes concentrations and clinical improvement as indicated by score changes with brief psychiatric rating scale (BPRS) and manic-state rating scale (MSRS). In addition, the correlations electrolytes after carbamazepine treatment and the changes of electrolytes concentration during the carbamzepine treatment was. also evaluated.
The author assessed 20 DSM-III diagnosed manic patients treated with carbamazepine, at average dose of 110mg/day, achieving mean±SD blood level of 7.93±0.49μg/ml (0.65-13.09μg/ml).
None of the patients had reading below 136mEq/L of sodiun concentration before carbamazepine therapy, but one (5070) did have such reading after carbamzepine treatment,
Among the 4 electrolytes, the concentration of calcium reduced significantly after carbamazepine treatment (P<0,02).
The total mean scores of BPRS and MSRS reduced significantly after carbamazepine treatment as P<0.02, P<0.01, respectively.
There was no correlation between the concentration changes of the electrolytes and score changes of BPRS and MSRS.
There were also no correlations between the mean carbamazepine concentrations and the concentration of the electrrolytes after carbamazepine treatment and the changes of electrolytes concentrations during the carbamazepine treatment.
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KEYWORD
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